Genderrisico.nl

Peer-reviewed figures by intervention and target group — side effects, complications and outcomes of gender care, with source citations.

More on this site: genderrisico.nl.

What Genderrisico.nl documents

Peer-reviewed figures on side effects, complications and outcomes of gender care. By intervention, target group and length of follow-up. No anecdotes, no advocacy — only the figures reported in the medical literature, with explicit source citations and methodological caveats.

Why this is needed

Existing Dutch patient information often describes risks in general terms ('as with any surgery') without quantification. This makes it impossible for patients to assess how substantial a specific risk is. Genderrisico fills that gap: the percentage of fistulas after vaginoplasty (substantial), the percentage of strictures after phalloplasty with urethral lengthening (high), the cardiovascular event rate with long-term oestrogen use (elevated), and detransition figures by length of follow-up (increasing over time).

How the figures are compiled

Three criteria:

• Peer-reviewed publication in medical journals;
• A sufficient sample size and length of follow-up — single case reports do not count;
• Methodological assessment: how was detransition defined, how long was follow-up conducted, and what selection bias may have occurred.

When conflicting studies are found, readers are presented with the range — not a forced average. Uncertainty intervals are deliberately prioritised over false precision.

Categories

• Hormonal risks: cardiovascular, hepatic, haematological, bone density, fertility and mental health.
• Surgical complications: by intervention — mastectomy, vaginoplasty, phalloplasty, metoidioplasty, FFS, orchiectomy.
• Regret and detransition: percentages by study, methodological evaluation, long versus short follow-up.
• Mental health before and after transition: depression, anxiety, suicidality and eating disorders — change over time, not a static picture.
• Pediatric-specific: the effects of blockers on bone density and brain development, and rates of progression to cross-sex hormones.

Target audience

Patients and families who want complete figures before making a decision. Healthcare providers who want to strengthen their informed consent protocols. Researchers looking for references. Lawyers working on detransition lawsuits. Journalists who need accurate figures.

Editorial approach

Strictly factual. No preferred interpretation. When one study reports high risks and another low risks, you receive both figures, with an explanation of why they differ. Methodological criticism is welcome; unpublished claims are not included.

Place within the network

The data dossier. Those arriving via Gender123 or Genderhub who need hard figures end up at Genderrisico. For stories that give the figures a human face: Genderellende. For current incidents: Gendergekte. For broad explanations: Genderinfo.

What is Genderrisico.nl?

Genderrisico is a dossier site that systematically compiles the medical risks and outcomes of gender care: figures and percentages by intervention, age group and outcome measure. Readers are given the material they need to make their own assessments.

What does it cover?

The site is organised around five main sections:

• Puberty blockers — bone density, brain development, fertility, sexual function and the question of whether treatment is 'reversible';
• Hormone therapy — cardiovascular risk, thrombosis, cancer risk, and hepatic and metabolic effects;
• Surgical interventions — complication rates for vaginoplasty, phalloplasty, mastectomy and FFS;
• Detransition and regret — prevalence of detransition, regret rates and reasons for returning;
• Prevalence and research reviews — national and international guidelines and systematic reviews (NICE, SBU, Cass).

Who is it for?

For patients and families considering a medical pathway, journalists seeking facts, policymakers evaluating guidelines and healthcare professionals who want to work with evidence. It is not intended to replace clinical advice, but to serve as a factual archive.

Tone and approach

Every claim includes a DOI or direct URL to the original publication. The site limits itself to published research and official bodies. International comparison is a central element: the British Cass Review, the Swedish policy change at Karolinska, the Finnish policy change and the Cochrane evaluations receive separate attention.

Place within the network

The network's data archive. Whereas this site (Genderinfo.nl) provides broad information, Genderrisico focuses on the empirical outcomes of care. For the Dutch healthcare model, the site refers readers to Dutchprotocol.nl; for international guidelines, to Wpath.nl.